Improvement of Kidney Apelin and Apelin Receptor in Nitro-L-Arginine-Methyl Ester Induced Rats
نویسندگان
چکیده
1. Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Tarbiat Modarres, Tehran, Iran 2. Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran 3. Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
منابع مشابه
Nitric oxide interferes with hypoxia signaling during colonic inflammation.
CONTEXT Intestinal inflammation can induce a local reduction in oxygen levels that triggers an adaptive response centered on the expression of hypoxia-inducible factors (HIFs). Nitric oxide, a well-described inflammatory mediator, may interfere with hypoxia signaling. OBJECTIVES We aimed to evaluate the role of nitric oxide in hypoxia signaling during colonic inflammation. METHODS Colitis w...
متن کاملNitric oxide synthase mediates the apelin-induced improvement of myocardial postischemic metabolic and functional recovery
The adipocytokine apelin is capable to reduce myocardial ischemia/reperfusion injury in rodents. Cardioprotective activity of apelin may be attributed to upregulation of endothelial nitric oxide synthase (eNOS). This study was designed to examine metabolic and functional effects of a synthesized 12 Cterminal residue of apelin (A-12) and N-nitro-L-arginine methyl ester (L-NAME), a non-selective ...
متن کاملApelin elevates blood pressure in ICR mice with L-NAME-induced endothelial dysfunction
Apelin is the endogenous ligand of APJ, which belongs to the family of G protein‑coupled receptors. Apelin and APJ are highly expressed in various cardiovascular tissues, including the heart, kidney and vascular endothelial and smooth muscle cells. Although apelin exerts hypotensive effects via activation of endothelial nitric oxide synthase (eNOS), the ability of apelin to regulate blood press...
متن کاملThe analgesic effect of apelin-13 and its mechanism of action within the nitric oxide and serotonin pathways.
BACKGROUND Apelin has various effects on a lot of systems such as central nervous system and cardiovascular system. This study investigated the possible analgesic effects of apelin-13 using the hot-plate and the tail-flick thermal analgesia tests in rats. We also evaluated the mechanism underlying the analgesic effects of apelin-13 by pretreating with Nw-nitro-L-arginine methyl ester (L-NAME) o...
متن کاملInteractions between apelin and angiotensin II on rat portal vein.
Apelin (AP), an endogenous ligand of the APJ receptor, is involved in the regulation of cardiovascular homeostasis. Regardless the multiple similarities between AP and angiotensin II (Ang II), their roles seem to be different. We studied both the interactions between Apelin 13 (AP13) and Ang II and to what extent, if any, nitric oxide (NO) is involved. The experiments were performed in endothel...
متن کامل